Central Oxford Structural Molecular Imaging Centre (COSMIC)

Managed by: Kavli Institute for Nanodiscovery

The Central Oxford Structural Molecular Imaging Centre (COSMIC) is a state-of-the-art cryo-electron microscopy facility in the South Parks Rd Science Area at Oxford University. Launched in 2016 in the Dunn School of Pathology and relocated to the new Biochemistry Phase II building in 2021, COSMIC facilitates an exciting and diverse range of structural biology research at Oxford. It is open both to researchers (including external to Oxford University) and to industry.

OSMIC comprises of a fleet of high end instrumentation and computing for every stage of the cryo-EM workflow:

  • FEI Talos 200 kV cryo-TEM with STEM detector for screening samples using negative staining and cryo-EM, as well as for cryo-tomography and cryo--STEM tomography
  • FEI Arctica 200 kV cryo-TEM with FEI Falcon 4 direct electron detector for high throughput screening of cryo-grids and single particle analysis
  • FEI Titan Krios 300 kV cryo-TEM with Gatan K3 direct electron detector + energy filter for high resolution single particle analysis, cryo-tomography and cryo-STEM tomography
  • Zeiss Crossbeam 550 cryo-FIB-SEM for cryo-lamella production and cryo-volume SEM
  • Three FEI Mark IV Vitrobots for preparing cryo-EM grids
  • High performance computing for data storage and processing
  • Dedicated staff to train and support users


Contact information

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