Facilitating world-class research
The Oxford Tropical Research Ethics Committee (OxTREC) is one of CUREC’s three subcommittees. It is responsible for reviewing the ethics of University medical research involving human participants and personal data which takes place outside the UK and the EU, or where the research is funded by the US National Institutes of Health or another US federal funding agency. OxTREC review does not replace the need for ethical review within the country where the research will take place.
The committee is constituted in accordance with the University regulations on CUREC subcommittees (Part 13 of Council Regulations 15 of 2002). These regulations, in conjunction with the standing orders of OxTREC, detail the remit of the committee, its responsibilities, requirements for quorum, and requirements (for the committee and researchers) for record keeping and audit.
The committee includes members from a range of academic and non-academic disciplines. Some members are internal to the University and have academic positions. Of the academic members, some are 'research active' but others are not currently involved in research with human participants or personal data.
The committee also has external members who bring valuable expertise and perspectives from non-academic and non-educational sectors. In this way it is hoped the members together reflect the interests of researchers, participants and third parties. Appointed members serve for four years and are re-eligible. For full details of committee membership requirements, see Part 13.8 of the Council Regulations.
Please note: any queries about the committee should be sent directly to email@example.com and not to individual members.
Secretary: Dr Rebecca Bryant
OxTREC delegates review of minimal risk applications to the OxTREC secretariat where appropriate. Minimal risk applications are reviewed on a rolling basis. All other applications are reviewed by the full committee, which meets six times a year.
Whether a study qualifies as minimal risk or not is a decision taken by OxTREC and not the applicant. See the OxTREC application process page for further information about the application process.
This table lists studies approved by OxTREC since January 2020.
This table lists studies approved by OxTREC since January 2019.
Recruitment and retention of pregnant women in Lassa fever drug and vaccine clinical trials: Perceptions of pregnant women and their health providers in a Lassa fever endemic zone
(ISRCTN registry: ISRCTN15668391)
Ethical considerations in decision-making for psychiatric inpatient admission without consent: insights from the South African legal, clinical, and sociocultural model
A multicentre cross-sectional survey to estimate the prevalence of Chronic Hepatitis B in pregnant women using an HBsAg point-of-care test
Lao PDR, Myanmar, Thailand, Indonesia, Democratic Republic of Congo, Burkina Faso, Nigeria, Brazil, Australia, United Kingdom
Characterisation of the nasopharyngeal microbiome in the first two years of life: further analysis of swabs from the Maela cohort
Diagnostic accuracy and usability of non-invasive POC tests for neonatal hyperbilirubinaemia in a resource-limited setting at the Thailand-Myanmar border
Investigating the Social and Biological Pathways of Health Disparities
Phaik Yeong Cheah
Ethical, Social, Regulatory and Market related aspects of Deploying Triple Artemisinin-Based Combination Therapies for Malaria treatment in Africa: Case studies in Burkina Faso and Nigeria
Mosquitocidal effect and pharmacokinetics of different ivermectin dose regimens in preparation for BOHEMIA cluster randomized controlled trial
A Randomized, Open-Label Study to Evaluate Potential Pharmacokinetic Interactions of Orally Administered Artemether-lumefantrine and Amodiaquine in Healthy Adult Subjects
Clinical trial (clinicaltrials.gov: NCT0408089)
Antibiotic use and Antimicrobial resistance (AMR) public awareness survey in Myanmar
An open-label, randomised, non-inferiority trial of the efficacy and safety of ciprofloxacin versus streptomycin + ciprofloxacin for the treatment of bubonic plague
Clinical trial (clinicaltrials.gov: NCT04110340)
This table lists studies approved by OxTREC since January 2018.
Oxford Sri Lanka Effects of Polluted Air on Rheumatic Heart Disease Study (OSLEOPARD)
This table lists studies approved by OxTREC since January 2017.
An open single-arm interventional study to identify the influence of human genetic variation on early transcriptional responses and protective immunity following immunization with rotavirus vaccine in Vietnamese infants
Fazle Rabbi Chowdhury
Is melioidosis a significant cause of febrile admissions for people with and without diabetes in Bangladesh?
Analysis of whole exome sequence data from the T2D-GENES project
Richard Gibbons and Sachith Mettananda
Co-inheritance of α-thalassaemia among patients with β-thalassaemia
Feasibility of the Nanobubble Technology for Detection of Malaria
Utilisation of a clinical microbiology service in a low income country paediatric hospital: the impact on antibiotic prescribing practices and barriers and facilitators to use
Prevention of mother-to-child transmission of hepatitis B virus (PMTCT-HBV): Hepatitis B Policy and Practice in Northern Thailand and Tenofovir in early pregnancy: a one arm, open label intervention study to estimate the optimal timing of Tenofovir (TDF)
A preliminary study towards understanding the potential role of Clinical Learning Systems in Kenya: Experiences and attitudes of key health and research stakeholders on the Kenyan Coast
Movement and migration patterns among a cohort of villagers from the Thailand-Myanmar border
A randomized double blind placebo controlled trial of adjunctive dexamethasone for the treatment of HIV-uninfected adults with tuberculous meningitis stratified by Leukotriene A4 hydrolase genotype
First Line Antimicrobials in Complicated Severe Acute Malnutrition
The diversity of the gut microbiota and its role in antimicrobial resistance gene circulation in healthy Vietnamese people
Lorenz von Seidlein
Safety and Immunogenicity evaluation of the malaria vaccine RTS,S/AS01, in healthy Thai adults
Strengthening South Africa’s health system through integrating treatment for mental illness into chronic disease care: A cluster randomized controlled trial
Targeted Research Advancing Sexual Health for Men who have sex with Men (TRANSFORM)
South Africa, Kenya
Nutrition in transition: local perceptions of under- and over-nutrition in pregnancy in marginalized Burman and Karen communities along the Thailand-Myanmar border
Trends in antimicrobial resistance in invasive bacterial infections in hospitalised Cambodian children, 2007-2016
Assessing the tolerability and safety of single low dose primaquine in African children with acute uncomplicated falciparum malaria and glucose 6 phosphate dehydrogenase deficiency (BAKMAL1606)
Uganda, Democratic Republic of Congo
Maria Chiara Rizzi
Testing the role of RDTs as a Point of Care tool in the early diagnosis of melioidosis: a pilot comparison with culture in Laos, an endemic region
Aiding computational phenotyping of facial features by inheritance modelling
The Scrub Typhus Antibiotic Resistance Trial (START). Comparing Doxycycline and Azithromycin Treatment Modalities in Areas of Reported Antimicrobial Resistance for Scrub Typhus
It was agreed by CUREC in early 2016 that, in the interest of transparency, OxTREC should make publicly available a list of studies that it has approved. The list below sets out those studies that have been approved by OxTREC since January 2016.